S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis.

Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD. However, the protective effects of SAC on the ischemic injury are not yet clear. In this study, we examined whether SAC could improve blood flow recovery in ischemic tissues through EPC-mediated neovasculogenesis. The results demonstrate that SAC significantly enhances the neovasculogenesis of EPCs in vitro. The molecular mechanisms for SAC enhancement of neovasculogenesis include the activation of Akt/endothelial nitric oxide synthase signaling cascades. SAC increased the expression of c-kit, β-catenin, cyclin D1, and Cyclin-dependent kinase 4 (CDK4) proteins in EPCs. Daily intake of SAC at dosages of 0.2 and 2 mg/kg body weight significantly enhanced c-kit protein levels in vivo. We conclude that dietary consumption of SAC improves blood flow recovery and prevents ischemic injury by inducing neovasculogenesis in experimental models

Circular Polarization in two Active Repeating Fast Radio Bursts

Fast radio bursts (FRBs) are bright millisecond radio bursts at cosmological distances. Only a small fraction of FRBs apparently repeat. Polarization, a fundamental property of electromagnetic signals, often carries critical information about the radiation processes, the environment, and the intervening medium of FRBs. Here we report circular polarization detections of two active repeating FRBs, namely FRBs 20121102A and 20190520B, with the Five-hundred-meter Aperture Spherical radio Telescope. We detect circular polarization in both active repeating FRBs, which increases the number of repeating FRBs with circular polarization to three. In one of the bursts of FRB 20121102A, we detect 64% degree of circular polarization. The observed circular polarization is unlikely induced by multipath propagation. Our observations favor circular polarization induced by Faraday conversion or radiation mechanism intrinsic to the FRB source. The conditions to generate circular polarization have to be rare in either case.Comment: 9pages, 3 figures, and 1 table, published in Science Bulleti

FRBs' Brownian Motion on Time-Energy Bivariate Space

The origin of fast radio bursts (FRBs), the brightest cosmic explosion in radio bands, remains unknown. Magnetar-related mechanisms are currently favored. The searches for short-term periodicity that is naturally expected for such fast-spinning compact objects, however, have failed. We introduce here a novel method for a comprehensive analysis of active FRBs' behaviors in the time-energy domain. Using ``Pincus Index'' and ``Maximum Lyapunov Exponent'', we were able to quantify the stochasticity and chaos, respectively, of the bursting events and put FRBs in the context of common transient physical phenomena, such as pulsars, earthquakes, and solar flares. In the bivariate time-energy domain, repeated FRB bursts' behaviors deviate significantly (more random, less chaotic) from pulsars, earthquakes, and solar flares. FRB bursts wander in time-energy space stochastically, akin to Brownian motions. The high degree of stochasticity suggests complex and even multi-origins for FRBs.Comment: 6 pages, 4 figures, submitte

Genetic variation analysis of reemerging porcine epidemic diarrhea virus prevailing in central China from 2010 to 2011

Porcine epidemic diarrhea has re-emerged with devastating impact in central China since October 2010. To investigate and analyze the reason of this outbreak, the M and ORF3 genes of 15 porcine epidemic diarrhea viruses (PEDV), which were collected from different areas of central China during October 2010 and December 2011, were amplified by reverse transcriptase polymerase chain reaction, cloned, sequenced, and analyzed. Sequence analyses showed that the nucleotides and amino acids were changed at some sites in the M and ORF3 genes of the 15 PEDV strains compared with those genes of CV777 reference strain. Based on the phylogenetic analyses, PEDVs in central China and reference strains could be separated into three groups: G1, G2, and G3. The 15 PEDV strains belonged to G3 group and showed a close relationship with Korean strains (2007), Thai strains (2007–2008), and partial other Chinese strains (2010–2011), but differed genetically from European strains (Br1/87) and the vaccine strain (CV777 vs) being used in China. Furthermore, all 15 PEDV strains from central China and some other isolates in China from 2003 to 2007 (LJB-03, QH, and LZC) belonged to different group. Therefore, PEDV exhibits rapid variation and genetic evolution, and the currently prevailing PEDV strains in central China are a new genotype

Changes in activities of both photosystems and the regulatory effect of cyclic electron flow in field-grown cotton (Gossypium hirsutum L) under water deficit

To clarify the influence of water deficit on the functionality of the photosynthetic apparatus of cotton plants, leaf gas exchange, chlorophyll a fluorescence, and P700 redox state were examined in field-grown cotton Gossypium hirsutum L. cv. Xinluzao 45. In addition, we measured changes in the P515 signal and analyzed the activity of ATP synthase and the trans-thylakoid proton gradient (ΔpH). With increasing water deficit, the net CO2 assimilation rate (AN) and stomatal conductance (gs) significantly decreased, but the maximum quantum efficiency of PSII photochemistry (Fv/Fm) did not change. The photochemical activity of photosystem II (PSII) was reflected by the photochemical quenching coefficient (qP), quantum efficiency of photosystem II [Y(II)], and electron transport rate through PSII [ETR(II)], while the activity of photosystem I (PSI) was reflected by the quantum efficiency of photosystem I [Y(I)] and the electron transport rate through PSI [ETR(I)]. Both activities were maintained under mild water deficit, but were slightly decreased under moderate water deficit. Under moderate water deficit, cyclic electron flow (CEF), the fraction of absorbed light dissipated thermally via the ΔpH- and xanthophyll-regulated process [Y(NPQ)], and the fraction of P700 oxidized under a given set of conditions [Y(ND)] increased. Our results suggest that the activities of both photosystems are stable under mild water deficit and decrease only slightly under moderate water deficit. Moderate water deficit stimulates CEF, and the stimulation of CEF is essential for protecting PSI and PSII against photoinhibition.This study was financially supported by the National Natural Science Foundation of China (U1203283; 31260295) and by the Training Program for Outstanding Young College Teachers (Grant No. CZ027201)